GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4332428 | 1 | rs5011018 | chr10:4967006 | AKR1C2 | chr10:4964715-5060207:- | 0.31 | 3.98 | 7.98E-5 | Height |
| THCA | cis | rs548987 | 1 | rs501220 | chr6:25873025 | BTN3A2 | chr6:26365398-26378546:+ | -0.25 | -4.64 | 4.46E-6 | Homocysteine levels |
| THCA | cis | rs1978968 | 1 | rs5013012 | chr22:18450149 | MICAL3 | chr22:18270418-18507325:- | -0.2 | -3.98 | 7.86E-5 | Presence of antiphospholipid antibodies |
| THCA | cis | rs1978968 | 1 | rs5013014 | chr22:18449927 | MICAL3 | chr22:18270418-18507325:- | -0.2 | -3.98 | 7.86E-5 | Presence of antiphospholipid antibodies |
| THCA | cis | rs472402 | 1 | rs501999 | chr5:6635601 | NSUN2 | chr5:6599355-6633157:- | 0.19 | 4.15 | 3.88E-5 | Response to amphetamines |
| THCA | cis | rs76248362 | 1 | rs5024798 | chr13:24440203 | C1QTNF9B | chr13:24465238-24471641:- | -0.36 | -3.71 | 0.00023 | 3-hydroxypropylmercapturic acid levels in smokers |
| THCA | cis | rs7665090 | 1 | rs5026472 | chr4:103554773 | CISD2 | chr4:103790135-103809913:+ | -0.16 | -3.72 | 0.000219 | Primary biliary cirrhosis |
| THCA | cis | rs7665090 | 1 | rs5026472 | chr4:103554773 | NFKB1 | chr4:103422486-103538458:+ | 0.15 | 4.13 | 4.2E-5 | Primary biliary cirrhosis |
| THCA | cis | rs7665090 | 1 | rs5026473 | chr4:103554793 | CISD2 | chr4:103790135-103809913:+ | -0.17 | -3.92 | 9.97E-5 | Primary biliary cirrhosis |
| THCA | cis | rs7665090 | 1 | rs5026473 | chr4:103554793 | NFKB1 | chr4:103422486-103538458:+ | 0.15 | 4.23 | 2.8E-5 | Primary biliary cirrhosis |
| THCA | cis | rs7665090 | 1 | rs5026476 | chr4:103554910 | CISD2 | chr4:103790135-103809913:+ | -0.16 | -3.62 | 0.000321 | Primary biliary cirrhosis |
| THCA | cis | rs7665090 | 1 | rs5026476 | chr4:103554910 | NFKB1 | chr4:103422486-103538458:+ | 0.15 | 4.2 | 3.16E-5 | Primary biliary cirrhosis |
| THCA | cis | rs11734488 | 1 | rs5028338 | chr4:139129127 | SLC7A11 | chr4:139085248-139163503:- | 0.23 | 4.55 | 6.95E-6 | Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect) |
| THCA | cis | rs477692 | 1 | rs503660 | chr10:131418999 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.55 | 2.2E-27 | Response to temozolomide |
| THCA | cis | rs683250 | 1 | rs505564 | chr11:83277912 | CCDC90B | chr11:82972506-82997414:- | 0.16 | 3.86 | 0.00013 | Subcortical brain region volumes |